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-0.06 Tc 0.06 Tw 8 0 0 8 230.2681 406.8001 Tm
(2006)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 248.1919 406.8001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 250.0098 406.8001 Tm
(354)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 263.4526 406.8001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 266.4225 406.8001 Tm
(3)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 270.9034 406.8001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 275.6913 406.8001 Tm
(241)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 289.1341 406.8001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 51.84 396.0001 Tm
(250)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 65.2828 396.0001 Tm
[(. doi: https:/)120 (/)100 (doi.or)10.1 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 143.0053 396.0001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 151.9672 396.0001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 153.6231 396.0001 Tm
(1056)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.01 Tc 0.01 Tw 9 0 0 9 171.5468 396.0001 Tm
[(/)-10 (N)-10 (EJ)5.1 (M)10 (oa)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 209.1483 396.0001 Tm
(043891)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 236.514 396.0001 Tm
( )Tj
-20.519 -1.2 Td
( )Tj
0.461 Tw 0 -1.2 Td
[(V)70 (a)10 (lderram)10 (a)10 (s SR)-19.9 (, A)15 (ta)10 (ll)10 (a)10 (h AN)30 (. E\037)15 (ecti)20 (v)20 (en)10 (ess an)10.1 (d s)5 (af)15 (et)15 (y of )]TJ
0.189 Tw 0 -1.2 Td
[(h)15 (y)10 (pertonic )0.5 (s)5 (a)10 (lin)10 (e )0.5 (in)10 (h)10 (a)10 (l)10 (ation )0.5 (c)10 (om)10 (bin)10 (ed )0.5 (with )0.5 (e)10 (x)10 (er)10 (ci)10 (s)5 (e trainin)10.1 (g )]TJ
0.382 Tw 0 -1.2 Td
[(in p)10 (atients with chr)10.1 (onic obstructi)20.1 (v)19.9 (e p)9.9 (ulm)10.1 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e: a )]TJ
0 Tw 0 -1.2 Td
[(ran)10 (domi)10.1 (z)10 (ed tri)10 (a)10 (l. )]TJ
/T1_2 1 Tf
[(Resp)5.1 (ir C)30 (ar)20 (e)]TJ
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 165.805 342.0001 Tm
(2009)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 183.7287 342.0001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 185.5467 342.0001 Tm
(54)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 194.5086 342.0001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 197.4785 342.0001 Tm
(3)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 201.9594 342.0001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 206.7472 342.0001 Tm
(327)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 220.19 342.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 222.6559 342.0001 Tm
(333)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 236.0987 342.0001 Tm
(.)Tj
-20.473 -1.2 Td
( )Tj
-0.158 Tw 0 -1.2 Td
[(Al)10 (bert RK)-20 (, C)30 (onn)10 (ett J)40 (, Baile)15 (y W)30 (C, et a)10 (l. Azithr)10 (om)15.1 (y)19.9 (cin f)15 (or pr)10 (e)20 (v)20 (ention )]TJ
0.086 Tw 0 -1.2 Td
[(of e)10 (x)10 (a)10 (c)10 (erb)10 (ation)10.1 (s of C)20 (OPD)40 (. )]TJ
/T1_2 1 Tf
0.079 Tw [(N E)15 (ngl J Med)]TJ
/T1_1 1 Tf
0 Tw (. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 215.1694 309.6001 Tm
(2011)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 233.0931 309.6001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 234.9111 309.6001 Tm
(365)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 248.3539 309.6001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 251.3238 309.6001 Tm
(8)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 255.8047 309.6001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 260.5926 309.6001 Tm
(689)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 274.0354 309.6001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 276.5013 309.6001 Tm
(698)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 289.944 309.6001 Tm
(. )Tj
-26.456 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 125.8366 298.8001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 134.7984 298.8001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 136.4544 298.8001 Tm
(1056)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.01 Tc 0.01 Tw 9 0 0 9 154.3781 298.8001 Tm
[(/)-10 (N)-10 (EJ)5.1 (M)10 (oa)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 191.9796 298.8001 Tm
(1104623)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 223.8262 298.8001 Tm
( )Tj
-19.11 -1.2 Td
( )Tj
0.282 Tw 0 -1.2 Td
[(H)20 (an MLK)-20 (, T)70 (a)25 (y)20 (ob N)30 (, Murra)25 (y S)10 (, et a)10 (l. Pr)10 (edictors of chr)10 (onic )]TJ
0.557 Tw 0 -1.2 Td
[(obstructi)20.1 (v)19.9 (e p)10 (ulm)10 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e e)10 (x)10 (a)10 (c)10 (erb)10 (ation r)10 (eduction in )]TJ
0.087 Tw 0 -1.2 Td
[(r)10 (es)10 (pon)10 (s)5 (e )0.5 (to )0.6 (d)10 (ail)5 (y )0.5 (a)20 (zithr)10.1 (om)15 (y)20 (cin )0.5 (th)10 (era)10 (p)15.1 (y)49.9 (. )]TJ
/T1_2 1 Tf
0.079 Tw 17.132 0 Td
[(A)25 (m J Resp)5 (ir C)20 (rit C)30 (ar)20 (e )]TJ
0 Tw -17.132 -1.2 Td
(Med)Tj
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 72.6566 244.8001 Tm
(2014)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 90.5803 244.8001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 92.3983 244.8001 Tm
(189)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 105.8411 244.8001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 108.811 244.8001 Tm
(12)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 117.7728 244.8001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 122.5607 244.8001 Tm
(1503)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 140.4844 244.8001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 142.9503 244.8001 Tm
(1508)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 160.8741 244.8001 Tm
(. )Tj
-12.115 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 125.8366 234.0001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 134.7984 234.0001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 136.4543 234.0001 Tm
(1164)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.01 Tc 0.01 Tw 9 0 0 9 154.3781 234.0001 Tm
[(/)40 (rcc)-10 (m)-10 (.)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 178.363 234.0001 Tm
(201402)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 205.2487 234.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 207.7146 234.0001 Tm
(0207)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 225.6383 234.0001 Tm
(OC )Tj
-19.311 -1.2 Td
( )Tj
0.057 Tw 0 -1.2 Td
[(S)20 (a)10 (l)10 (ath)10 (e M. R)10 (eg)10 (ul)10 (ation )0.5 (of m)10 (amm)10 (a)10 (li)10.1 (an cili)10 (ary be)15 (atin)10.1 (g)49.9 (. )]TJ
/T1_2 1 Tf
0.052 Tw [(A)25 (nnu Rev )]TJ
0 Tw 0 -1.2 Td
[(P)10 (hy)10 (siol)]TJ
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 82.4937 201.6002 Tm
(2007)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 100.4175 201.6002 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 102.2354 201.6002 Tm
(69)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 111.1973 201.6002 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 114.1672 201.6002 Tm
(1)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 118.6481 201.6002 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 123.436 201.6002 Tm
(401)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 136.8788 201.6002 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 139.3447 201.6002 Tm
(422)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 152.7875 201.6002 Tm
(. )Tj
-11.216 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 125.8366 190.8001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 134.7984 190.8001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 136.4543 190.8001 Tm
(1146)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 154.3781 190.8001 Tm
[(/)90 (annur)10 (e)20 (v)50 (.ph)15.1 (y)10 (siol.)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 219.4383 190.8001 Tm
(69)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 228.4002 190.8001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 230.0561 190.8001 Tm
(040705)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 256.9417 190.8001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 258.5976 190.8001 Tm
(141253)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 285.9633 190.8001 Tm
( )Tj
0.161 Tw -26.014 -2.4 Td
[(M)10 (ats)10 (ui )0.5 (H, )0.5 (Gru)10 (bb )0.5 (BR)-20 (, )0.5 (T)70 (arran )0.5 (R)-20 (, )0.5 (et a)10 (l. )0.5 (E)30 (viden)10 (c)10 (e )0.5 (f)15 (or )0.5 (pericili)10 (ary )]TJ
0.471 Tw 0 -1.2 Td
[(liquid l)10 (a)25 (y)20 (er depletion, n)10 (ot a)10 (bn)10 (orm)10 (a)10 (l ion c)9.9 (om)10.1 (position, in )]TJ
0.497 Tw 0 -1.2 Td
[(th)10 (e p)10 (ath)10 (ogen)10 (esi)10.1 (s of c)10 (y)10 (stic \036)10 (br)10 (osi)10 (s airw)15 (a)25 (y)10 (s di)10 (s)5 (e)15 (a)10 (s)5 (e)10 (. )]TJ
/T1_2 1 Tf
0 Tw [(C)30 (ell)]TJ
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 51.8399 136.8001 Tm
(1998)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 69.7636 136.8001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 71.5816 136.8001 Tm
(95)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 80.5435 136.8001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 83.5134 136.8001 Tm
(7)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 87.9943 136.8001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 92.7821 136.8001 Tm
(1005)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 110.7059 136.8001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 113.1718 136.8001 Tm
(1015)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 131.0955 136.8001 Tm
(. )Tj
-8.806 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 125.8365 126.0001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 134.7984 126.0001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 136.4543 126.0001 Tm
(1016)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.015 Tc 0.015 Tw 9 0 0 9 154.3781 126.0001 Tm
(/S)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 163.171 126.0001 Tm
(0092)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 181.0947 126.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 183.5606 126.0001 Tm
(8674)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 201.4843 126.0001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 204.4542 126.0001 Tm
(00)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 213.4161 126.0001 Tm
(\))Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 216.386 126.0001 Tm
(81724)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 238.7907 126.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 241.2565 126.0001 Tm
(9)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 245.7375 126.0001 Tm
(m )Tj
-21.544 -1.2 Td
( )Tj
0.215 Tw 0 -1.2 Td
[(S)10 (chmid A)-20 (, Ba)10 (umlin N)30 (, Iv)20 (onn)10 (et P)49.9 (, et a)10 (l. R)10 (o\035)15 (umil)10 (a)10.1 (st p)10 (arti)10.1 (a)10 (ll)5 (y )]TJ
0.229 Tw 0 -1.2 Td
[(r)10 (e)20 (v)20 (ers)5 (es sm)10.1 (ok)10 (e-in)10 (duc)10 (ed muc)10 (ocili)10 (ary dy)10 (sfun)10 (ction. )]TJ
/T1_2 1 Tf
0.209 Tw [(Resp)5.1 (ir Res)]TJ
/T1_1 1 Tf
0 Tw (. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 51.8399 82.8001 Tm
(2015)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 69.7636 82.8001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 71.5816 82.8001 Tm
(16)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 80.5435 82.8001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 83.5134 82.8001 Tm
(1)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 87.9943 82.8001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 92.7821 82.8001 Tm
(135)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 106.2249 82.8001 Tm
[(. doi: https:/)120.1 (/)100 (doi.or)10.1 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
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-0.06 Tc 0.06 Tw 8 0 0 8 183.9474 82.8001 Tm
(10)Tj
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/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 192.9093 82.8001 Tm
(.)Tj
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/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 194.5652 82.8001 Tm
(1186)Tj
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-0.09 Tc 0.09 Tw 9 0 0 9 212.489 82.8001 Tm
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-0.06 Tc 0.06 Tw 8 0 0 8 219.5359 82.8001 Tm
(12931)Tj
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0 Tc 0 Tw 9 0 0 9 241.9406 82.8001 Tm
(-)Tj
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/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 244.4065 82.8001 Tm
(015)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 257.8493 82.8001 Tm
(-)Tj
0 0 0 0.9 scn
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/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 260.3152 82.8001 Tm
(0294)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 278.2389 82.8001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 280.7048 82.8001 Tm
(3)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 285.6657 82.8001 Tm
( )Tj
-25.981 -1.2 Td
( )Tj
ET
/GS0 gs
q 1 0 0 1 34.82 384.0002 cm
0 0 m
255.6 0 l
S
Q
q 1 0 0 1 34.82 330.5602 cm
0 0 m
255.6 0 l
S
Q
q 1 0 0 1 34.82 287.1594 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
/TT0 1 Tf
7.5 0 0 7.5 36.4398 374.8544 Tm
(75.)Tj
-0.096 -7.184 Td
(76.)Tj
0 -5.787 Td
(77.)Tj
ET
/GS0 gs
q 1 0 0 1 35.86 221.9007 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.7598 212.3145 Tm
(78.)Tj
ET
/GS0 gs
q 1 0 0 1 35.9 438.16 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.7998 428.5739 Tm
(74.)Tj
ET
/GS0 gs
q 1 0 0 1 35.56 654.9401 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.4598 645.3538 Tm
(70.)Tj
ET
/GS0 gs
q 1 0 0 1 35.56 599.9401 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.4598 590.3538 Tm
(71.)Tj
ET
/GS0 gs
q 1 0 0 1 35.56 718.98 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.4598 709.3938 Tm
(69.)Tj
ET
/GS0 gs
q 1 0 0 1 35.72 178.5186 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.6198 168.9325 Tm
(79.)Tj
ET
/GS0 gs
q 1 0 0 1 36 113.8849 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 36.8998 104.2988 Tm
(80.)Tj
ET
/GS0 gs
q 1 0 0 1 319.68 503.1 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 320.5798 493.5139 Tm
(84.)Tj
ET
/GS0 gs
q 1 0 0 1 321.12 448.4193 cm
0 0 m
255.6 0 l
S
Q
BT
/GS1 gs
7.5 0 0 7.5 322.0198 438.8331 Tm
(85.)Tj
/T1_1 1 Tf
-0.114 Tw 9 0 0 9 336.96 709.2001 Tm
[(F)85 (a)10 (bbri L)10 (M, C)30 (a)10 (l)5 (v)20 (erle)15 (y P)25 (M)10 (A)-20 (, I)20 (z)10 (quier)10.1 (do-)15 (Alon)10 (s)5 (o JL, et a)10 (l. R)10 (o\035)15.1 (umil)10 (a)10 (st )]TJ
0.196 Tw 0 -1.2 Td
[(in m)10 (oderate-)-20 (to-s)5.1 (e)20 (v)20 (er)10 (e chr)10 (onic obstructi)20.1 (v)19.9 (e p)10 (ulm)10 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e )]TJ
0.499 Tw 0 -1.2 Td
[(tr)10 (e)15 (ated with lon)10.1 (g-a)10 (ctin)10 (g br)9.9 (on)10.1 (ch)10 (odil)10 (ators: tw)5 (o ran)10 (domi)10.1 (s)5 (ed )]TJ
0.195 Tw 0 -1.2 Td
[(clinic)10 (a)10 (l tri)10 (a)10 (l)10 (s. )]TJ
/T1_2 1 Tf
0 Tw [(L)10 (ancet)]TJ
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 424.0678 676.8001 Tm
(2009)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 441.9916 676.8001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 443.8095 676.8001 Tm
(374)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 457.2523 676.8001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 460.2222 676.8001 Tm
(9691)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 478.146 676.8001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 482.9338 676.8001 Tm
(695)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 496.3766 676.8001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 498.8425 676.8001 Tm
(703)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0.195 Tw 9 0 0 9 512.2853 676.8001 Tm
[(. doi: https:/)120.1 (/)100 (doi.)]TJ
0 Tw -19.481 -1.2 Td
[(or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 353.7628 666.0001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 362.7247 666.0001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 364.3806 666.0001 Tm
(1016)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.015 Tc 0.015 Tw 9 0 0 9 382.3043 666.0001 Tm
(/S)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 391.0972 666.0001 Tm
(0140)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 409.021 666.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 411.4869 666.0001 Tm
(6736)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 429.4106 666.0001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 432.3805 666.0001 Tm
(09)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 441.3423 666.0001 Tm
(\))Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 444.3123 666.0001 Tm
(61252)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 466.7169 666.0001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 469.1828 666.0001 Tm
(6)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 474.1437 666.0001 Tm
( )Tj
-15.243 -1.2 Td
( )Tj
0.196 Tw 0 -1.2 Td
[(M)10 (artin)10.1 (e)9.9 (z F)70 (J)40 (, C)30 (a)10 (l)5 (v)20 (erle)15 (y P)25 (M)10 (A)-20 (, Goehrin)10 (g U)15 (M, Br)10 (os)5 (e M, F)85 (a)10 (bbri )]TJ
0.057 Tw 0 -1.2 Td
[(L)10 (M, Ra)10 (be KF)70 (. E\037)15 (ect of r)10 (o\035)15.1 (umil)10 (a)10 (st on e)10 (x)10 (a)10 (c)10 (erb)10 (ation)10 (s in p)10 (atients )]TJ
-0.035 Tw 0 -1.2 Td
[(with s)5 (e)20 (v)20 (er)10 (e chr)10 (onic obstructi)20.1 (v)20 (e p)10 (ulm)10 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e un)10 (c)10 (ontr)10 (olled )]TJ
0.21 Tw 0 -1.2 Td
[(b)15 (y c)10 (om)10 (bin)10 (ation th)10 (era)10 (p)15 (y \(RE)10 (A)30 (C)20 (T\): a multic)10.1 (entr)10 (e ran)10 (domi)10 (s)5 (ed )]TJ
0 Tw 0 -1.2 Td
[(c)10 (ontr)10 (olled tri)10.1 (a)10 (l. )]TJ
/T1_2 1 Tf
[(L)10 (ancet)]TJ
/T1_1 1 Tf
(. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 426.0763 601.2001 Tm
(2015)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 444.0001 601.2001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 445.818 601.2001 Tm
(385)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 459.2608 601.2001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 462.2307 601.2001 Tm
(9971)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 480.1544 601.2001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 484.9423 601.2001 Tm
(857)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 498.3851 601.2001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 500.851 601.2001 Tm
(866)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 514.2938 601.2001 Tm
(. )Tj
-19.704 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 410.9567 590.4001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 419.9185 590.4001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 421.5744 590.4001 Tm
(1016)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.015 Tc 0.015 Tw 9 0 0 9 439.4982 590.4001 Tm
(/S)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 448.2911 590.4001 Tm
(0140)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 466.2148 590.4001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 468.6807 590.4001 Tm
(6736)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 486.6045 590.4001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 489.5743 590.4001 Tm
(14)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 498.5362 590.4001 Tm
(\))Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 501.5061 590.4001 Tm
(62410)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 523.9108 590.4001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 526.3766 590.4001 Tm
(7)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 531.3376 590.4001 Tm
( )Tj
-21.598 -1.2 Td
( )Tj
0.154 Tw 0 -1.2 Td
[(M)10 (artin)10.1 (e)9.9 (z )0.6 (F)70 (J)40 (, )0.5 (Ra)10 (be )0.6 (KF)70 (, )0.5 (S)10 (ethi )0.5 (S)10 (, )0.6 (et )0.5 (a)10 (l. )0.6 (E\037)15 (ect )0.5 (of )0.6 (r)10 (o\035)15 (umil)10 (a)10 (st )0.6 (an)10 (d )]TJ
0.699 Tw 0 -1.2 Td
[(in)10 (h)10 (a)10 (led c)10 (ortic)10.1 (oster)10 (oid/lon)10 (g-a)10.1 (ctin)10 (g b)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
0 Tw 8 0 0 8 486.5222 558.0001 Tm
(2)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0.699 Tw 9 0 0 9 491.0031 558.0001 Tm
[(-a)10 (goni)10.1 (st on chr)10 (onic )]TJ
0.38 Tw -17.116 -1.2 Td
[(obstructi)20.1 (v)19.9 (e )0.5 (p)10 (ulm)10 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e e)10 (x)10 (a)10 (c)10 (erb)10 (ation)10.1 (s \(RE)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
0 Tw 8 0 0 8 536.7795 547.2001 Tm
(2)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 541.2604 547.2001 Tm
[(SPOND)10 (\): )]TJ
0.418 Tw -22.7 -1.2 Td
[(A ran)10 (domi)10 (z)10 (ed clinic)10 (a)10 (l tri)10 (a)10.1 (l. )]TJ
/T1_2 1 Tf
0.382 Tw [(A)25 (m J Resp)5.1 (ir C)20 (rit C)30 (ar)20 (e Med)]TJ
/T1_1 1 Tf
0 Tw (. )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 336.96 525.6001 Tm
(2016)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 354.8838 525.6001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 356.7017 525.6001 Tm
(194)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 370.1446 525.6001 Tm
(\()Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 373.1144 525.6001 Tm
(5)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 377.5954 525.6001 Tm
(\):)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 382.3832 525.6001 Tm
(559)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 395.826 525.6001 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 398.2919 525.6001 Tm
(567)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 411.7347 525.6001 Tm
(. )Tj
-8.308 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 410.9567 514.8002 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 419.9185 514.8002 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 421.5744 514.8002 Tm
(1164)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.01 Tc 0.01 Tw 9 0 0 9 439.4982 514.8002 Tm
[(/)40 (rcc)-10 (m)-10 (.)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 463.4831 514.8002 Tm
(201607)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 490.3687 514.8002 Tm
(-)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 492.8346 514.8002 Tm
(1349)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 510.7584 514.8002 Tm
(OC )Tj
-19.311 -1.2 Td
( )Tj
0.089 Tw 0 -1.2 Td
[(Ch)10 (on)10 (g J)40 (, L)10 (e)10 (un)10.1 (g B)10 (, P)19.9 (oole P)50 (. Ph)10 (os)10 (ph)10 (odiestera)10.1 (s)5 (e )]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
0 Tw 8 0 0 8 519.0292 493.2001 Tm
(4)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0.089 Tw 9 0 0 9 523.5101 493.2001 Tm
[( in)10.1 (hi)10 (bitors f)15 (or )]TJ
0.332 Tw -20.728 -1.2 Td
[(chr)10 (onic obstructi)20 (v)20 (e p)10 (ulm)10 (on)10 (ary di)10 (s)5 (e)15 (a)10 (s)5 (e)10 (. )]TJ
/T1_2 1 Tf
0.303 Tw [(C)30 (ochr)20 (ane Databas)10.1 (e )]TJ
0 Tw 0 -1.2 Td
[(S)30 (y)10 (st Rev)40.1 (.)]TJ
/T1_1 1 Tf
( )Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 371.3844 471.6001 Tm
(2017)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 389.3081 471.6001 Tm
(;)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
8 0 0 8 391.1261 471.6001 Tm
(9)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
9 0 0 9 395.607 471.6001 Tm
(:CD)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 410.3578 471.6001 Tm
(002309)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 437.2434 471.6001 Tm
(. )Tj
-11.143 -1.2 Td
[(doi: https:/)120.1 (/)100 (doi.or)10 (g/)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 410.9567 460.8001 Tm
(10)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 419.9186 460.8001 Tm
(.)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 421.5745 460.8001 Tm
(1002)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 9 0 0 9 439.4982 460.8001 Tm
(/)Tj
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 443.5032 460.8001 Tm
(14651858)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.04 Tc 0.04 Tw 9 0 0 9 479.3507 460.8001 Tm
[(.C)-40 (D)]TJ
0 0 0 0.9 scn
/GS0 gs
/TT0 1 Tf
-0.06 Tc 0.06 Tw 8 0 0 8 493.5795 460.8001 Tm
(002309)Tj
0 0 0 1 scn
/GS1 gs
/T1_1 1 Tf
-0.01 Tc 0.01 Tw 9 0 0 9 520.4651 460.8001 Tm
[(.)-10 (pub)]TJ
0 0 0 0.9 scn
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